[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"nav-categories":3,"article-an-85-trial-prediction-claim-is-not-the-same-as-clinical-proof":45,"article-ads":218},{"data":4},[5,32,39],{"name":6,"slug":7,"categories":8},"Technology","tech",[9,12,16,20,24,28],{"id":10,"title":6,"slug":11},28,"technology",{"id":13,"title":14,"slug":15},37,"Creator Economy","creator-economy",{"id":17,"title":18,"slug":19},20,"Work","work",{"id":21,"title":22,"slug":23},22,"Finance","finance",{"id":25,"title":26,"slug":27},31,"YouTube Blog","youtube-blog",{"id":29,"title":30,"slug":31},21,"For newbies","for-newbies",{"name":33,"slug":34,"categories":35},"News","news",[36],{"id":37,"title":33,"slug":38},18,"quasanews",{"name":40,"slug":41,"categories":42},"Business","business",[43],{"id":44,"title":40,"slug":41},16,{"post":46,"published_news":76,"popular_news":131,"categories":209},{"title":47,"description":48,"meta_title":49,"meta_description":50,"meta_keywords":51,"text":52,"slug":53,"created_at":54,"publish_at":55,"first_published_at":55,"updated_at":54,"formatted_created_at":56,"category_id":29,"links":57,"view_type":62,"video_url":63,"views":64,"likes":65,"lang":66,"comments_count":65,"is_indexable":67,"response_status":63,"category":68,"translations":75},"An 85% Trial Prediction Claim Is Not the Same as Clinical Proof","QuantHealth’s vendor-reported 85% trial prediction accuracy is an audit starting point, not proof of safety or efficacy. Its value depends on timing, scoring and independent validation.","Why 85% Trial Prediction Accuracy Is Not Clinical Proof","QuantHealth’s reported 85% prediction accuracy is not clinical proof. Audit its timing, endpoints, calibration, coverage and independent validation.","in-silico trials, trial prediction accuracy, clinical simulation evidence, model calibration, external validation, reproducibility, regulatory context","\u003Cp>QuantHealth’s vendor-reported 85% trial prediction accuracy does not establish that a treatment is safe or effective. It can support development decisions, but only after the underlying cases, prediction timing, endpoint scoring and validation have been examined.\u003C/p>\u003Cp>The decisive question is not whether 85% sounds high. It is whether the figure represents locked forecasts made before trial readouts, scored against prespecified primary endpoints, calibrated across relevant diseases and reproduced outside the developer’s control.\u003C/p>\u003Ch2>Reconstruct what the 85% measures\u003C/h2>\u003Cp>\u003Ca href=\"https://quanthealth.ai/evidence\" target=\"_blank\" rel=\"nofollow noopener\">QuantHealth’s evidence page\u003C/a> reports an 85% primary-endpoint accuracy rate across more than 120 simulated trials and characterizes its prospective validation as prediction before readout without sponsor data. It lists IMVOKE010, TROPION-Breast01 and ELOQUENT1 as examples. These are the company’s claims; the public page does not provide the complete trial-level dataset needed to calculate the figure independently.\u003C/p>\u003Cp>Begin by asking whether more than 120 trials is the actual denominator for the 85% calculation or a broader count of simulations. A suitable trial-level record would identify every eligible study, any exclusion, the simulation date, the information cutoff, the predicted result, the observed result and the scoring rule. Without it, a reader cannot determine how missing, ambiguous or selectively presented cases affected the percentage.\u003C/p>\u003Cp>The unit of accuracy matters too. A binary prediction of whether a primary endpoint will be met is different from predicting its effect size, confidence interval or clinical significance. A model can classify a narrow miss and a decisive failure identically, or correctly predict a pass while materially misestimating the treatment effect.\u003C/p>\u003Ch2>Separate prospective prediction from retrospective fit\u003C/h2>\u003Cp>Retrospective analysis can test feasibility and expose failure modes, but it is not prospective forecasting. If an outcome was already known, if post-readout information entered the inputs, or if developers selected the best result from several runs after seeing the answer, the exercise measures fit rather than a locked prediction.\u003C/p>\u003Cp>For each prospective claim, request evidence that the data cutoff, model version, endpoint interpretation and output were frozen before the trial result became public. The audit trail should identify one prespecified run rather than merely show that some simulation occurred earlier. It should also record who controlled the timestamp and whether the result was registered with an independent party.\u003C/p>\u003Cp>“Without sponsor data” needs its own inventory. Public protocols, earlier trials, conference abstracts, regulatory documents and results from related compounds may contain powerful signals. Using them is not necessarily a weakness, but the claim should distinguish biological simulation from synthesis of already available evidence.\u003C/p>\u003Ch2>Ask for calibration and relevant coverage\u003C/h2>\u003Cp>Accuracy counts correct classifications under a chosen rule. \u003Cstrong>Calibration\u003C/strong> tests whether stated probabilities match observed frequencies: across a sufficiently large evaluation set, outcomes assigned a 70% probability should occur at roughly that rate. A model can have acceptable classification accuracy while consistently expressing too much confidence.\u003C/p>\u003Cp>Calibration should be reported with uncertainty intervals and enough cases to interpret it. Pooled results can conceal limited evidence in a particular phase, therapeutic area, modality or endpoint family. Broad platform coverage therefore does not demonstrate validated performance in every covered disease.\u003C/p>\u003Cp>A useful comparison also needs a baseline evaluated on the same locked cases. Depending on the decision, that might be a historical success rate, a simple model based on phase and disease, or structured expert judgment. An 85% score has less incremental value if a substantially simpler method performs similarly.\u003C/p>\u003Ch2>Look for external validation and reproducibility\u003C/h2>\u003Cp>The evidence base for in-silico trials remains uneven. An \u003Ca href=\"https://arxiv.org/abs/2503.08746\" target=\"_blank\" rel=\"nofollow noopener\">independent systematic review\u003C/a> identified 202 publications and 48 registered trials, including 76 articles directly connected to drug development. Its detailed reproducibility assessment found that 18 of those 76 articles, or 24%, supplied an open-source model implementation, while generated synthetic data were publicly available in 20%.\u003C/p>\u003Cp>The review also found that in-silico methods were still uncommon within registered clinical trials and concentrated in particular diseases. That does not invalidate a commercial model, but it limits any inference from broad labels such as “validated across therapeutic areas.” Performance must be demonstrated in cases resembling the disease, phase, modality and endpoint for the proposed use.\u003C/p>\u003Cp>Commercial software need not be public to undergo a credible evaluation. An unaffiliated team can test a frozen model on trials withheld from development under controlled data access. The protocol should be set before outcomes are known and should state who chose the cases, applied exclusions, ran the model and adjudicated ambiguous endpoints.\u003C/p>\u003Ch2>Match the evidence standard to the decision\u003C/h2>\u003Cp>Simulation evidence can have legitimate regulatory and development roles without replacing clinical evidence. The \u003Ca href=\"https://www.fda.gov/science-research/about-science-research-fda/modeling-simulation-fda\" target=\"_blank\" rel=\"nofollow noopener\">FDA’s modeling and simulation overview\u003C/a> describes computational methods as complementing bench, animal and clinical evidence, and says FDA scientists review industry modeling results and use such approaches in regulatory decision-making. It does not say that a vendor’s aggregate accuracy rate independently proves safety or efficacy.\u003C/p>\u003Cp>The required validation therefore depends on the \u003Cstrong>context of use\u003C/strong>. Prioritizing indications or stress-testing protocol assumptions can tolerate different uncertainty from replacing a control arm or supporting an effectiveness claim. The audit must name the decision, the population to which the result will be applied and the consequence of a false positive or false negative.\u003C/p>\u003Ch2>A claim-audit worksheet\u003C/h2>\u003Cul>\u003Cli>\u003Cstrong>Claim:\u003C/strong> Record the exact metric, denominator, unit of analysis, exclusions and scoring rule.\u003C/li>\u003Cli>\u003Cstrong>Endpoint:\u003C/strong> Specify the registered primary endpoint and whether the prediction covers pass or fail, direction, effect size and uncertainty.\u003C/li>\u003Cli>\u003Cstrong>Timing:\u003C/strong> Establish when inputs, model version and output were frozen relative to public and sponsor readouts.\u003C/li>\u003Cli>\u003Cstrong>Data access:\u003C/strong> List sponsor, public, historical and related-program information available before prediction.\u003C/li>\u003Cli>\u003Cstrong>Calibration:\u003C/strong> Request probability calibration, uncertainty intervals, missing-case handling and subgroup sizes.\u003C/li>\u003Cli>\u003Cstrong>Coverage:\u003C/strong> Map the intended disease, phase, modality and endpoint family to comparable evaluation cases.\u003C/li>\u003Cli>\u003Cstrong>External validation:\u003C/strong> Identify who selected the test set, ran the frozen model and adjudicated outcomes.\u003C/li>\u003Cli>\u003Cstrong>Reproducibility:\u003C/strong> Determine whether versions, inputs, outputs and evaluation code can be independently audited under suitable confidentiality controls.\u003C/li>\u003Cli>\u003Cstrong>Context of use:\u003C/strong> State the decision being supported and the cost of an incorrect prediction.\u003C/li>\u003C/ul>\u003Cp>An 85% prediction claim may be scientifically and commercially useful. Until these fields are filled, however, it remains a vendor-reported aggregate with undetermined generalizability and evidentiary weight—not clinical proof.\u003C/p>\n\n\u003Cp>Also read:\u003C/p>\n\n\u003Cul>\n\t\u003Cli>\u003Ca href=\"/media/data-encryption-and-why-governments-claim-to-need-backdoors\">Data Encryption and Why Governments Claim to Need Backdoors\u003C/a>\u003C/li>\n\t\u003Cli>\u003Ca href=\"/media/francois-chollet-s-radical-new-definition-of-agi-it-s-not-about-automation-it-s-about-human-like-skill-acquisition\">François Chollet’s Radical New Definition of AGI: It’s Not About Automation — It’s About Human-Like Skill Acquisition\u003C/a>\u003C/li>\n\t\u003Cli>\u003Ca href=\"/media/china-is-winning-the-ai-race-not-just-with-open-source-models-but-with-unmatched-speed-of-real-world-implementation\">China Is Winning the AI Race Not Just with Open-Source Models — But with Unmatched Speed of Real-World Implementation\u003C/a>\u003C/li>\n\u003C/ul>","an-85-trial-prediction-claim-is-not-the-same-as-clinical-proof","2026-08-09T15:31:05.000000Z","2026-08-16T07:00:00.000000Z","16.08.2026",{"image":58,"image_webp":59,"thumb":60,"thumb_webp":61},"https://cdn.quasa.io/images/news/zcOyRkUxBGTktEELdu2PTbxmpxFRq1oTxmdBJZtQ.jpg","https://cdn.quasa.io/images/news/zcOyRkUxBGTktEELdu2PTbxmpxFRq1oTxmdBJZtQ.webp","https://cdn.quasa.io/thumbs/news-thumb/images/news/zcOyRkUxBGTktEELdu2PTbxmpxFRq1oTxmdBJZtQ.jpg","https://cdn.quasa.io/thumbs/news-thumb/images/news/zcOyRkUxBGTktEELdu2PTbxmpxFRq1oTxmdBJZtQ.webp","large",null,3,0,"en",true,{"id":29,"title":30,"slug":31,"meta_title":69,"meta_description":70,"meta_keywords":71,"show_on_homepage":72,"deleted_at":63,"created_at":73,"updated_at":74,"lang":66},"For Newbies: Business, Startups and AI Tools | QUASA","How to start a business, find early investment, choose a direction and use modern AI tools.","for newbies, start a business, investment, AI tools, startup ideas",false,"2021-10-25T14:55:26.000000Z","2026-07-16T20:17:45.000000Z",[],[77,80,93,106,118],{"title":47,"description":48,"slug":53,"created_at":54,"publish_at":55,"first_published_at":55,"updated_at":54,"formatted_created_at":56,"category":78,"links":79,"view_type":62,"video_url":63,"views":64,"likes":65,"lang":66,"comments_count":65,"is_pinned":72},{"title":30,"slug":31},{"image":58,"image_webp":59,"thumb":60,"thumb_webp":61},{"title":81,"description":82,"slug":83,"created_at":84,"publish_at":85,"first_published_at":85,"updated_at":84,"formatted_created_at":56,"category":86,"links":87,"view_type":62,"video_url":63,"views":92,"likes":65,"lang":66,"comments_count":65,"is_pinned":72},"Public AI Leaderboards Miss the System Around the Model","Public model rankings cannot show whether an AI agent fits a startup’s workflow. 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Check the test method, fire compliance, appearance retention, construction and cleaning compatibility.","5-things-to-check-when-choosing-commercial-fabrics-for-upholstery","2021-12-13T20:33:33.000000Z","2024-01-23T09:56:00.000000Z","2026-08-14T13:31:17.000000Z","23.01.2024",{"title":40,"slug":41},{"image":158,"image_webp":63,"thumb":159,"thumb_webp":159},"https://cdn.quasa.io/images/news/LkhtE7o5QGYAqJmbMi8hLmr1lvZ0OKn6r0qRlk52.webp","https://cdn.quasa.io/thumbs/news-thumb/images/news/LkhtE7o5QGYAqJmbMi8hLmr1lvZ0OKn6r0qRlk52.webp",55671,{"title":162,"description":163,"slug":164,"created_at":165,"publish_at":166,"first_published_at":166,"updated_at":167,"formatted_created_at":168,"category":169,"links":170,"view_type":175,"video_url":63,"views":176,"likes":177,"lang":66,"comments_count":178,"is_pinned":72},"More Views Aren’t a Revenue Plan: 5 Moves for Content Creators","Creators can earn more by pairing platform reach with direct offers, recurring revenue and disciplined pricing. 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However, this is far from the truth. Website surfing, or browsing websites for rewards, is an accessible way to earn money or cryptocurrency with just a computer or smartphone and an internet connection.One of the easiest methods to generate income in the digital space is through website surfing. The tasks involved are so simple that virtually anyone can participate, regardless of experience or technical expertise.In this article, we’ll introduce you to a platform where you can start earning money and cryptocurrency through website surfing: Quasa Rewards.","earning-money-through-website-surfing-a-simple-way-to-make-cryptocurrency","2025-09-26T10:51:12.000000Z","2025-12-11T10:51:12.000000Z","11.12.2025",{"id":37,"title":33,"slug":38,"meta_title":233,"meta_description":234,"meta_keywords":235,"show_on_homepage":67,"deleted_at":63,"created_at":236,"updated_at":74,"lang":66},"Technology, AI, Space and Robotics News | QUASA","Important technology, AI, space and robotics news from the US, Europe, China, India and the rest of the world.","technology news, AI news, space, robotics, technology companies","2021-08-09T19:09:44.000000Z",{"image":238,"image_webp":239,"thumb":240,"thumb_webp":241},"https://cdn.quasa.io/images/news/YSiJuxDAmWhSW9FRj9ySKpji0y7gn3H3M7GejA0x.jpg","https://cdn.quasa.io/images/news/YSiJuxDAmWhSW9FRj9ySKpji0y7gn3H3M7GejA0x.webp","https://cdn.quasa.io/thumbs/news-thumb/images/news/YSiJuxDAmWhSW9FRj9ySKpji0y7gn3H3M7GejA0x.jpg","https://cdn.quasa.io/thumbs/news-thumb/images/news/YSiJuxDAmWhSW9FRj9ySKpji0y7gn3H3M7GejA0x.webp",9256,{"id":244,"order":65,"created_at":245,"expired_at":246,"news_id":247,"post":248},86,"2026-06-07T14:36:10.000000Z","2029-06-07 14:35:45",4545,{"id":247,"title":133,"description":134,"slug":135,"created_at":136,"publish_at":137,"formatted_created_at":139,"category":249,"links":250,"view_type":62,"video_url":63,"views":146,"likes":147,"lang":66,"comments_count":63},{"id":37,"title":33,"slug":38,"meta_title":233,"meta_description":234,"meta_keywords":235,"show_on_homepage":67,"deleted_at":63,"created_at":236,"updated_at":74,"lang":66},{"image":142,"image_webp":143,"thumb":144,"thumb_webp":145},{"id":252,"order":178,"created_at":253,"expired_at":254,"news_id":255,"post":256},92,"2026-06-07T15:05:49.000000Z","2033-06-07 15:05:26",13757,{"id":255,"title":257,"description":258,"slug":259,"created_at":260,"publish_at":261,"formatted_created_at":262,"category":263,"links":268,"view_type":175,"video_url":63,"views":273,"likes":64,"lang":66,"comments_count":63},"The State of Hybrid Freelance 2026: AI, Web3 and the Death of Traditional Work (Update June 2026)","New industry data from QUASA: How AI and Web3 are destroying traditional work in 2026. Download the full report.","report-2026","2026-02-02T08:38:20.000000Z","2026-07-04T15:26:00.000000Z","04.07.2026",{"id":17,"title":18,"slug":19,"meta_title":264,"meta_description":265,"meta_keywords":266,"show_on_homepage":72,"deleted_at":63,"created_at":267,"updated_at":74,"lang":66},"Remote Work, Freelancing and Careers | QUASA","Remote and hybrid work, freelancing, ways to earn, careers and labor-market changes around the world.","remote work, freelancing, earnings, hybrid work, careers","2021-09-03T20:21:41.000000Z",{"image":269,"image_webp":270,"thumb":271,"thumb_webp":272},"https://cdn.quasa.io/images/news/GD0ptwC1dSdOUluvqyI6Hkay9pmmzOQGaJPpn1ib.jpg","https://cdn.quasa.io/images/news/GD0ptwC1dSdOUluvqyI6Hkay9pmmzOQGaJPpn1ib.webp","https://cdn.quasa.io/thumbs/news-thumb/images/news/GD0ptwC1dSdOUluvqyI6Hkay9pmmzOQGaJPpn1ib.jpg","https://cdn.quasa.io/thumbs/news-thumb/images/news/GD0ptwC1dSdOUluvqyI6Hkay9pmmzOQGaJPpn1ib.webp",7920,{"id":275,"order":276,"created_at":277,"expired_at":278,"news_id":279,"post":280},89,2,"2026-06-07T14:54:22.000000Z","2030-06-07 14:54:10",14533,{"id":279,"title":281,"description":282,"slug":283,"created_at":284,"publish_at":285,"formatted_created_at":286,"category":287,"links":288,"view_type":175,"video_url":63,"views":293,"likes":64,"lang":66,"comments_count":63},"Quasa Projects: The PPC Advertising Platform Powering the New Crypto Economy","The global PPC advertising market is more than 1,000 times larger than the old surfing niche — operating in the hundreds of billions of dollars.","quasa-projects-the-ppc-advertising-platform-powering-the-new-crypto-economy","2026-05-16T17:26:37.000000Z","2026-05-17T14:40:00.000000Z","17.05.2026",{"id":37,"title":33,"slug":38,"meta_title":233,"meta_description":234,"meta_keywords":235,"show_on_homepage":67,"deleted_at":63,"created_at":236,"updated_at":74,"lang":66},{"image":289,"image_webp":290,"thumb":291,"thumb_webp":292},"https://cdn.quasa.io/images/news/imwxgJ055ISr1tlKGDQLYBQFaE0ub84LDZnW3gvo.jpg","https://cdn.quasa.io/images/news/imwxgJ055ISr1tlKGDQLYBQFaE0ub84LDZnW3gvo.webp","https://cdn.quasa.io/thumbs/news-thumb/images/news/imwxgJ055ISr1tlKGDQLYBQFaE0ub84LDZnW3gvo.jpg","https://cdn.quasa.io/thumbs/news-thumb/images/news/imwxgJ055ISr1tlKGDQLYBQFaE0ub84LDZnW3gvo.webp",6011,{"id":295,"order":64,"created_at":296,"expired_at":297,"news_id":298,"post":299},90,"2026-06-07T14:56:33.000000Z","2030-06-07 14:56:17",14531,{"id":298,"title":300,"description":301,"slug":302,"created_at":303,"publish_at":304,"formatted_created_at":286,"category":305,"links":306,"view_type":175,"video_url":63,"views":311,"likes":64,"lang":66,"comments_count":63},"Quasa Rewards: The World’s First and Only Crypto Platform for Earning by Surfing Websites","If you’re looking for the easiest and smartest way to start earning crypto online, Quasa Rewards is the clear choice.","quasa-rewards-the-world-s-first-and-only-crypto-platform-for-earning-by-surfing-websites","2026-05-16T16:17:13.000000Z","2026-05-17T14:01:00.000000Z",{"id":37,"title":33,"slug":38,"meta_title":233,"meta_description":234,"meta_keywords":235,"show_on_homepage":67,"deleted_at":63,"created_at":236,"updated_at":74,"lang":66},{"image":307,"image_webp":308,"thumb":309,"thumb_webp":310},"https://cdn.quasa.io/images/news/ES2wTuQRXXbpqrqE49nXtNegIQZi6ECYODo1Jpd9.jpg","https://cdn.quasa.io/images/news/ES2wTuQRXXbpqrqE49nXtNegIQZi6ECYODo1Jpd9.webp","https://cdn.quasa.io/thumbs/news-thumb/images/news/ES2wTuQRXXbpqrqE49nXtNegIQZi6ECYODo1Jpd9.jpg","https://cdn.quasa.io/thumbs/news-thumb/images/news/ES2wTuQRXXbpqrqE49nXtNegIQZi6ECYODo1Jpd9.webp",1134,{"id":313,"order":64,"created_at":314,"expired_at":315,"news_id":298,"post":316},94,"2026-06-07T16:58:25.000000Z","2033-06-07 16:58:13",{"id":298,"title":300,"description":301,"slug":302,"created_at":303,"publish_at":304,"formatted_created_at":286,"category":317,"links":318,"view_type":175,"video_url":63,"views":311,"likes":64,"lang":66,"comments_count":63},{"id":37,"title":33,"slug":38,"meta_title":233,"meta_description":234,"meta_keywords":235,"show_on_homepage":67,"deleted_at":63,"created_at":236,"updated_at":74,"lang":66},{"image":307,"image_webp":308,"thumb":309,"thumb_webp":310}]